DOE for HPLC analytical method development under QBD framework

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moh
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DOE for HPLC analytical method development under QBD framework

how design of experiments are done for hplc method development. pleaze give the suggestions regarding which type of DOE are most suitable.

Dr. Analytical
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This is a very general

This is a very general question.  If you understand DOE then you know that there are many options.  I think a simple 2 level factorial design is easy if you only have tthree variables (8 experiments).  I always like to add a center point so the total rimber experiments  is 9. 

If you have software, then you can do more complex experiments, but this is very expensive.