Artificial skin model for teating of adhesion of transdermal devices

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Kirils
Kirils's picture
Artificial skin model for teating of adhesion of transdermal devices

I need to evaluate the performance of adhesives in our transdermal products with use on sweaty skin. I cannot afford cadaver or other naturally sourced products. What artificial membranes are available for this type of product evaluation that would simulate human epidermis?

Thanks!

Fraser Moss
Fraser Moss's picture
How about going to your local

How about going to your local butcher at acquiring some pig skin? Just make sure it is used within 48h.

It is a known method.

Alternatively I found this patent (United States Patent 5911165) describing a PVC based membrane system.

http://www.patentstorm.us/patents/5911165-fulltext.html

Kirils
Kirils's picture
Pig skin in too inconsistant

Pig skin in too inconsistant and doesn't really represent human skin very well as far as permeation goes.

If the PVC membrane is gas permeable I could attach an isotonic fluid source behind it to produce the required vapor pressure under an occlusive dressing. I will look into this PVC item ASAP. Thank you, your advise is appreciated!

K

ghunter
ghunter's picture
what makes you believe that

what makes you believe that PVC membranes are closer to human skin?

Kirils
Kirils's picture
Kirils wrote:I need to

Kirils wrote:

I need to evaluate the performance of adhesivesproducts. What artificial
 
I have found the Mat Tek Epidermal to be the best along with a franz cell.  Problem is that it is too expensive.  Cadaver, pig skin and PVC is too inconsistant with their pemeation rates.  Pay a volunteer and use a microtome to get the sample. It seems to work consistantly.
A co-worker of mine is testing a semi-solid gradient system in a pressure vessle.  A patent is in the works.  His device is inexpensive, except for reagents.  I feel he has winner here.
Kirils 
Kvachhani
Kvachhani's picture
Hi,

Hi,
How is to use adult poultry probebly broiler skin, as thickness and other parameters are mostly similar to human and easily abailable also with economicaly affordable.
Regards.