Hello, I'd have a query!
Which is the meaning of a "negative" membrane conductance?
I record cell membrane capacitance in whole cell mode and during my Cm measurements, I record Gm too. Usually, that's constant in a range of 0.2-2 nanoSiemens.
Recently, I'm getting some capacitance measurements with a negative Gm, around 0.5-1 nS, constant but negative.
I can't understand what's happening and above all, I have a preoccupation: could that affect values of Cm? Traces of Cm look nice, with increase when I stimulate exocytosis. But could this negative Gm have an effect on behaviour of Cm?
Could anyone please help me?
Thanks so much. Regards.