Patch clamp configuration for ion selectivity measurements

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nnitzan1
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Patch clamp configuration for ion selectivity measurements

Hi everybody

I'm new here and wanted to ask what patch clamp configurations are most suitable for selectivity measurements and why. I previously used whole cell config. to characterize selectivity in HEK cells,
obviously in outseide-out also possible
but I also saw some publication of selectivity measurements in inside-out config. - what possible advantage might this have?

Thanks !