Micro-anatomy of brain resources?

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Graeme E. Smith
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Micro-anatomy of brain resources?

I am working on a theory of memory that requires that I confirm micro-anatomical detail about how nerves are organized in different areas of the cortex and organs of the brain. Is there a practical resource I can use to do this?

The FFM
The FFM's picture
Have you tried the Allen

Have you tried the Allen Brain Atlas?
http://www.brain-map.org/
 
or The Human Brain Atlas www.thehumanbrain.info/ ?
 
ALso look at lab web sites of researchers who investigate learning and memory. e.g. the Tonegawa lab at MIT http://tonegawalab.org/
 
Also www.smithsrisca.demon.co.uk/neuro-micro.html
and www.wisc-online.com/objects/index_tj.asp
brain.oxfordjournals.org/cgi/content/full/128/1/158
 www.neuroscience-gateway.org/2008/080207/full/ngw1805.shtml
http://www.jneurosci.org/cgi/content/full/20/15/5827
Look up any articles on the "Trisynaptic Pathway"

Graeme E. Smith
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Well that was a nice list of

Well that was a nice list of resources, the first two were brain atlases, unfortunately although you can zoom in on brain atlases, most of them are not that easy to read once you get to the micro-anatomy.
I am sure some of the others might have been quite useful if I was studying mice, or knew a particular researcher within the company to ask for.
The Brodman article would have been valuable if there had been actual drawings of the differences between the Brodmann areas micro-anatomy, and if there were work done since the 1930s.Frankly the Wikipedia article was easier to read because it used the Grey Anatomy version of the Brodmann map.
And then there were those wonderfol articles on the Trisynaptic pathway, which while it will help with my work on the Declarative Memory won't be much use on the Architecture of the Neo-cortex, being mainily involved with the hippocampus and entorhinal cortex.. By the way, does anyone know if the pyramidal cells of the entorhinal cortex are in the exact same layers and relations to the stellate and basket cells as in the Neocortex? I dearly want to compare them to the drawing in Marr's "A theory for the Cerebral Neocortex" It also won't help with my interest in what the sensory inputs in the Visual cortex are doing in Layer IV
I don't want to seem ungrateful, I mean I am asking for free resources, but a little more thought to what I need would be nice, I would rather have one good staining study comparing Brodmann areas, than all the Brain Atlases and triysynaptic pathway articles suggested so far.

The FFM
The FFM's picture
Rodent neuroanatomy generally

Rodent neuroanatomy generally serves as suitable model to understand the neurocicuitary of humans.  Hence the generation of hundreds of mouse knock-in and knock-out lines which are used in such studies.
Now that you have provided more precise details than "organs of the brain" ( which probably includes the hippocampus, the trisynaptc pathway and entorhinal cortex, "nerves" and "cortex"  I hope that someone can help you find that precise resource that you need.
Please included as much information as possible in the original post and then the responses you will receive will be more focused on your needs.  I will keep looking for you.

Graeme E. Smith
Graeme E. Smith's picture
Thank you for clarifying the

Thank you for clarifying the Mouse connection.I'll go back and look a little more carefully at the mouse related links you offered. Sorry I wasn't more careful with my original request, I must admit to being new here and not yet knowing the proper etiquet. To clarify, My current project involves comparisons of the Pyramidal Areas of the various cortexes. Of especial interest is where the micro-architecture changes from the Layer 1 Mossy Dendrite Neurons, Layer 2/3 Pyramidal Neurons, Layer 4 stellite and Basket Neurons, Level 5 and 6 Pyramidal Neurons  Pattern suggested by Marr's diagram. I was recently shown an article on the Martinotti cells of various layers that surround the columns in the neocortex. But it is mostly the Pyramidal cells, and the stellate/basket cells that interest me.

The FFM
The FFM's picture
Graeme

Graeme
 
Here is a new resource that you might find useful for this work
BrainNavigator: Interactive Atlas and 3D Brain Software for Research, Structure Analysis, and Education
http://elsatglabs.com/bnmicrosite/home.html

 
You can register for a free trial here www.surveymonkey.com/s.aspx
 
and attend a webinar here tinyurl.com/ppzhon