hypoglycemia

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Jubendradass
Jubendradass's picture
hypoglycemia

Hi

 can decresed GLUT-2 expression in liver  causes hypoglycemia ? if so please tell me the possible reasons with references

Thank you

g a
g a's picture
hi jubendradass

hi jubendradass

Check the following article.

doi:10.1016/j.febslet.2005.09.060    

R Bishop
R Bishop's picture
Actually, in mice deficient

Actually, in mice deficient in GLUT-2 HYPERGLYCEMIA is the phenotype not hypoglycemia.  As to the cause, the animals are unable to take up glucose in the liver because GLUT-2 is the major glucose receptor on hepatocytes.

References -

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes
http://www.pnas.org/content/95/21/12317.full

The Bishop