can decresed GLUT-2 expression in liver causes hypoglycemia ? if so please tell me the possible reasons with references
Check the following article.
Actually, in mice deficient in GLUT-2 HYPERGLYCEMIA is the phenotype not hypoglycemia. As to the cause, the animals are unable to take up glucose in the liver because GLUT-2 is the major glucose receptor on hepatocytes.
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocyteshttp://www.pnas.org/content/95/21/12317.full