thermosensitive chitosan formulation

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KH
KH's picture
thermosensitive chitosan formulation

I've been trying to develop a thermosensitive formulation using chitosan in the same way a lot of other papers have done but actually it didn't gel as the papers says

the only way I tried and got a result is using poloxamer
Does any body know why the chitosan don't form gel upon heating using any of the methods mentioned in the papers
i.e. + beta glycerphosphate

+ PVA

+ DHO

+ AHP

none of these methods give results although mentioned in many papers

may be because of the specs of the chitosan?