The Kanzius Cancer Cure: What Do you Think?

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The Kanzius Cancer Cure: What Do you Think?

CBS 60 minutes did a segment on the Kanzius Cancer Cure today.

Nobel Prize-winning chemist Richard Smalley believes inventor John Kanzius might have uncovered the missing piece in the search for a cure for cancer.

http://www.cbsnews.com/stories/2008/04/10/60minutes/main4006951.shtml

Kanzius RF Therapy, cancer cells are first tagged with tiny objects known as nanoparticles, such as SWNTs[1] and GNPs.[5] When the RF (radio frequency) transmitter apparatus exposes the nanoparticles to the radio frequency signal they heat up, destroying the cancer cells, but don't damage healthy cells nearby.[6]

As of 2007-04-23, preliminary research using the Kanzius RF device at the M. D. Anderson Cancer Center in Houston (by Dr. Steven A. Curley, Professor in Surgical Oncology[7][8]) and The University of Pittsburgh Medical Center (by Dr. David A. Geller, co-director of the Liver Cancer Center[9]) has shown promising results. If federal approval is granted, testing on human patients would be the next step.[6] [10] [4]

In contrast with currently used radiofrequency ablation where an RF probe (needle) is inserted into or next to a tumor mass, Kanzius' method is noninvasive.[3]

Steven A. Curley, who pioneered the clinical studies that led to FDA approval of radiofrequency ablation to treat unresectable primary and metastatic hepatobiliary malignancies[7], referred to the method as “one of the most exciting developments in years.”[11]

The prototype of the device, which was first tested successfully[2] at University of Pittsburgh Medical Center by Klune et al.[2] was built by Kanzius himself in his home.[9]

As of 1st November 2007, preliminary trials with rabbits have turned up a 100% success rate, with the tumors successfully eliminated and the rabbits remaining unharmed. [1]

R Bishop
R Bishop's picture
Like all "cures", this method

Like all "cures", this method will depend upon the ability to target SWNTs to cancer-specific antigens without targeting host cells. The authors of this study have done the 2 easy experiments i.e. killing cultured cells and directly injecting particles into tumor masses in a rabbit. The next step will be simple in concept but difficult due to range of antigens presented on any given cancer cell and normal cells.

I think this technology might be extremely powerful for targeting bacteria and other infectious microorganisms, which often carry specific cell surface markers not found in the host.

original article link - http://www3.interscience.wiley.com/cgi-bin/abstract/116834125/ABSTRACT?CRETRY=1&SRETRY=0

Rb

g a
g a's picture
Do these nanoparticles cross

Do these nanoparticles cross BLOOD BRAIN BARRIER too?
There are similiar reports however efficacy of the following will depend upon the total half life of these nano particles in circulation as well as in their capability to cross the BLOOD BRAIN barrier........

vaxman
vaxman's picture
Many of these techniques are

Many of these techniques are easy to demonstrate in models, but how do you get precise placement in a patient with metastatic disease? Most of the animal models of cancer have little similarity to humans with advanced disease. The field is loaded with therapies that looked very promising in the models but failed misearbly in clinical trials.

Kanzius Cancer ...
Kanzius Cancer Research Foundation's picture
A year ago on Feb. 18, John

A year ago on Feb. 18, John Kanzius lost his battle with cancer. We think he’d be proud of the Kanzius Cancer Research Foundation’s accomplishments during the past 12 months. Why not take a moment to share your thoughts on John Kanzius' accomplishments or to support his vision with a gift in his memory.  
Let’s continue to “spread the wave”…for John.
-Kanzius Cancer Research Foundation: Spread the Wave

the sciencist
the sciencist's picture
 1.can somebady explain me

 1.can somebady explain me why this nanoparticules  are absorbet only by the tumour cells and not by the normal cells??/
2.is this tested in humnas does this destroys cancers in humans ??
3.it looks easy why the cancer is still unbeaten when we have this  can somebody answer to my questions please...

g a
g a's picture
 Dear Scientist

 Dear Scientist

1) Nanoparticles can be linked to biological molecules which can act as address tags, to direct the nanoparticles to specific sites within the body, specific organelles within the cell,or to follow specifically the movement of individual protein or RNA molecules in living cells. Common address tags are monoclonal antibodiesaptamersstreptavidin or peptides. These targeting agents should ideally be covalently linked to the nanoparticle and should be present in a controlled number per nanoparticle. Multivalent nanoparticles, bearing multiple targeting groups, can cluster receptors, which can activate cellular signaling pathways, and give stronger anchoring. 

2) Nanoparticles are present as components in many products that we use regularly such as sun screens.... However, their large scale interactions and its effect on living system are yet unknown and are currently being explored.

3)Finally, A cancer cell is the smartest thing to have ever existed.... Your body has about 100 trillion cells and all nucleated cells are capable of transforming into cancer cell. Beating a cancer cell is a daunting task but many promising treatment methods and preventive ones are there.

the sciencist
the sciencist's picture
 becouse they are

 becouse they are nanoparticules they can enter in all cells including normal cells and tumour cells  so they can enter by the diffusion  in membranas helthy cell  so my question is how it enters only in tumour cells and not in normal cell  how???