Peptides causing cancer

6 posts / 0 new
Last post
g a
g a's picture
Peptides causing cancer

Dear All

I have been injecting mice with synthetic Peptides for raising antibodies. After almost 6-7months the last booster given mice have developed tumors. To be more specific only the female mouse have developed tumors and not the male.

The peptide was chosen from a protein that is involved in the breast cancer induction and increases the incidence of BRCA involving breast cancers by 2fold.

Can there be any correlation ??????

pearlpraba
pearlpraba's picture
praise the lord my dear

praise the lord my dear friend my suggestion
we intend to test whether normal cells from the blood stream of breast cancer patients called dendritic cells have the ability to stimulate immunity against breast cancer. The dendritic cells are normally present in small numbers in the blood, and stimulate immunity very strongly against viruses, bacteria, cancer cells and other foreign invaders. Scientists have developed a way to grow these cells in large numbers outside the body within a week after removing a sample of blood and exposing the white blood cells to growth factors that encourage the growth of dendritic cells. In this research project, dendritic cells will then be exposed to a synthetic piece of a substance present on breast cancer cells called "CEA" that is present on tumors from two thirds of patients with breast cancer. Dendritic cells will be grown for a week outside the body and then exposed to a fragment of the "CEA", followed by infusion in large numbers into the veins of patients with breast cancer that has spread widely and cannot be cured with chemotherapy, radiation or surgery. Increasing doses of the cells will be given to groups of at least three patients with breast cancer in order to find out whether the dendritic cells cause side effects when given twice over a period of two weeks. Stimulation of the immune system against breast cancer will be measured before and after the dendritic cells are given by removing a sample of blood for analysis in the laboratory and by other tests. Shrinkage of tumor will also be measured. In this 2 year trial of 24 patients with metastatic breast cancer, we will ask whether patients that receive CEA dendritic cells can increase their immunity against breast cancer without side effects, and whether increased immunity against breast cancer can cause shrinkage of tumors.

The long term goal of this initial study is to find ways to educate the immune system to recognize and destroy breast cancer cells even though the presence of the tumor and the chemotherapy agents used to shrink the breast cancer have caused decreased levels of immunity. The results of this initial CEA dendritic cell study will determine the course of future studies depending on whether shrinkage of tumor is seen, in which case a follow-up study will be performed to confirm that CEA dendritic cells are effective for the treatment of metastatic breast cancer. If no tumor shrinkage is seen, but immunity against breast cancer is boosted, then patients will be treated with CEA dendritic cells and then have a blood sample removed to try to grow another type of white blood cell called killer T cells that can be directed against breast cancer. This use of dendritic cells to stimulate immunity against breast cancer is supported by work showing that in the mouse and in humans, dendritic cells are the strongest stimulators of the immune system. This immunologic approach to breast cancer is an attempt to harness the body’s natural defenses to eliminate tumors by boosting the immune response directed against a substance found on cancer cells.

g a
g a's picture
Dear  Pearlpraba

Dear  Pearlpraba

Can you suggest any possible reasons for the development of these tumors?
I have checked up the origin of these tumors and found they both were of breast origin, solid, nonmetastatic tumors.

pearlpraba
pearlpraba's picture
praise the lord my dear

praise the lord my dear friend TUMOR DEVELOPS DUE TO FAILURE IN APOTOPSIS

g a
g a's picture
Hi Pearlpraba

Hi Pearlpraba

I think most of us are aware of that fact. I have been working in the tumor proteomics of blood plasma for last 6 years. What I was implying was if you can suggest any mechanism or have come across any similar results then please quote.

thanx

Zhu Milk
Zhu Milk's picture
Peptides causing cancer?

Firstly, anything can "cause" cancer. thats a fact. problem is "cause" is a difficult word to use with cancer.I don't think the issue with peptides like IGF or ones that boost growth hormone are actually causing cancer. I think the issue is if you have a cancerous tumor or even a tumor - that tumor is more likely to grow or get worse. If you have a family history of this - or suspect you may have a tumor - you should be getting regular check-ups from your doctor and avoiding all GH boosting products (that includes hgh as well).