Status of Immunity in Cancer

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g a
g a's picture
Status of Immunity in Cancer

Hi all
I have recently collected alot of data of the cancer patients in north India. To my surprize I figured out that most of the tumor patients have developed Leukopenia and in general the lymophocyte count were reduced in almost all cancer types I took. Is it A generalized mechanism for escaping the immune surveillance by the tumor or is it the Counter response of the tumor progression that peripheral circulation is showing alterations in their pattern as lymphocytes and neutrophils might be irected towards the site of tumor progression?
The tumors in question are epithelioid or carcinomas of lung, breast and ovary?

Omai
Omai's picture
Hi Argerine,

Hi Argerine,
I'm not a tumor biologist, but as an infectious disease researcher, I find this result very interesting. In the little bit of research I did on the topic, it looks like most of the leukopenia or neutropenia is due to cancer treatment and not the tumor progression itself. Is the data you have collected on treated or untreated patients?
 
Omai

g a
g a's picture
Hi Omai

Hi Omai
Even my first guess was the same as yours that leucopenia and lymphopenia are resultant of the therapy. However the samples were even showing same results for the CBC analysis before undergoing any therapy. very few of the reports had normal levels, some even had higher values than standards but mostly it was Low count.
 

vaxman
vaxman's picture
While most leucopenia results

While most leucopenia results from cytotoxic drug therapy or radiation, some cancer cells secrete factors which inhbit maturation of dendritic cells. This can affect circulating lymphcoyte counts, as can tumor cells secreting soluble Fas (CD95) ligand, which can kill Fas+ CTL.

Stephannie Baker
Stephannie Baker's picture
Life sciences

This thread is very insightful with so much information. I never really thought of something like this. Having breakthrough for treatment of cancer is such a vast research field with no set treatment guaranteeing total healing of the patient from cancer. The information collected by you seems very useful