Is human Angiogenin inside the cell or on the cell surface?

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life analyzer
life analyzer's picture
Is human Angiogenin inside the cell or on the cell surface?

Does anybody know whether human angiogenin is inside the cell or on the cell surface? Do all kind of human cells have it? Its concentration inside the cell is low or kind of high? Thanks a lot.

saswati1
saswati1's picture
The protein is endocytosed

The protein is endocytosed and translocated from the cell surface to the nucleus and goes to the nucleoli in endothelial cells. PLease read the following paper

http://www.pnas.org/cgi/reprint/91/5/1677.pdf#search=%22angiogenin%20is%20inside%20the%20cell%20or%20on%20the%20cell%20surface%22

guohui
guohui's picture
well,thanks.

well,thanks.