I would like to target a cytoplasmic protein to the plasma membrane. I want it to insert in the cell membrane and form a receptor with exposed domains on both sides. The protein is naturally capable of localising to the membrane by itself sometimes, but i want to enforce it's exptression at the cell membrane constitutively. I believe the way to do it is to add a signal sequence to import it into ER. Has anyone done this before? Are any references like published papers available where they have shown this a is a viable method? Need help with the theory as well as practical execution of the xept.