Chromatin Dynamics and Higher Order Organization

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Chromatin Dynamics and Higher Order Organization

Keystone Symposia
Organizers: Terumi Kohwi-Shigematsu and Patrick D. Varga-Weisz
February 25 - March 2, 2009 • Coeur d'Alene Resort • Coeur d'Alene, Idaho

Research in the past decade has revealed the intimate link of chromatin structure at the levels of histone modifications and nucleosome remodeling to nuclear functions, especially gene regulation. Yet the molecular mechanisms of higher orders of chromatin organization beyond the nucleosomal array remain largely obscure. Evidence is emerging that chromatin folding and large-scale chromatin interactions, including trans-interactions between chromosomes, play an important role in gene regulation, recombination, and other nuclear processes. Chromatin looping may be a key component of regulatory mechanisms. New roles of non-coding RNAs in regulating chromatin function are also uprising. Furthermore, functional compartments, such as transcription factories, replication factories, and polycomb bodies have been suggested to organize the nucleus. This meeting will focus on recent breakthroughs in our understanding of the mechanisms that govern dynamics of higher-order chromatin architecture in order to gain important insights into gene regulation and disregulation, DNA repair, normal development, stem cell function, epigenetic inheritance and diseases such as cancer.

Meeting program:

Registration deadline is coming up soon!