whole slide imaging

8 posts / 0 new
Last post
Lisa M.
Lisa M.'s picture
whole slide imaging

I am looking into whole slide imaging systems, we are evaluating the Aperio and I am interested in the Panoramic SCAN from CRI.  I also know Leica has one as well. Any recommendations?

robertr's picture
Don't forget about MikroScan

Don't forget about MikroScan www.mikroscan.com who are (based in Vista, CA not far from Aperio) new and have very compelling costs, with performance / features that is as good or better than most other options.

Dr. Keith Kaplan at "Digital Pathology Blog" covered them here:
- Whole slide scanner for arounf $30k: http://goo.gl/7q6Fm
- Another Scanner Company: http://goo.gl/NmUKq

There are some demo videos here: http://www.mikroscan.com/whole-slide-scanners/demo-videos/

Victor Casas
Victor Casas's picture




/* Style Definitions */
{mso-style-name:"Table Normal";
mso-padding-alt:0in 5.4pt 0in 5.4pt;
font-family:"Times New Roman";

From the sounds of it, it sounds like you’re setting up a new high throughput Digital Pathology system for your histology lab.    This is a complex, but exciting process, but one that is fraught with decisions that will impact your lab for years to come.   A fully functional digital pathology system starts with “Core Viewing Software”.   We’d recommend before even making any kind of decision on a brand of scanner, that you look into the viewing software which best suits your needs.   We’ve found that a “vendor neutral” slide viewing company usually best provides the kind of flexibility that a medical or laboratory facility would desire going into a decision with such a dramatic impact on the future.   Do you really want to be stuck with the limitations of a product line from a single vendor, or would you rather have an a viewing and communications tool which will allow you from the beginning to choose from any and all hardware vendors?   mScope from Aurora Imaging is just that kind of software.  It can read and display images from any manufacturer’s scanning system, which allows you to not be “stuck” with a particular name brand for good, simply because at this time they had the best feature set on their hardware?   Get the best hardware, sure, but don’t make the error of thinking that the software that you get with your viewer is that which is required.
After you’ve selected the software, then consider your scanning needs throughout the medical center.   Is a single scanner in the histology lab the right way to go?   If a Pathologist has a “special case” he’d like to share, or needs a quick consult on a pending case, can he or she interrupt the daily workflow of the scanner?   What about Frozen Sections?   Does the move into digital pathology cover the literal tens to hundreds of thousands of dollars in savings over a period of time by placing a simple scanner in the Frozen Section room of your hospital, and allowing a PA to cut, stain, and scan the specimen and the Pathologist to do the frozen analysis by opening a window at his desk rather than trudging over, sometimes driving over to Frozen, changing, scrubbing, etc (and the savings multiply if you serve multiple hospitals).   What about remote facilities, where perhaps there’s a few specimens a week that can be cut and scanned locally without the cost of shipping the slides to you?    It’s best to go over all of your digital pathology needs before deciding on the big scanner, then lay out a map of what you’ll need.   In our experience, we have seen the needs for, in any given medical center, Viewing and Communications Software, One High Throughput Digital Slide scanner and 2-5 small single slide scanners (One for Frozen Sections, One in the Pathology Offices for Tumor Boards and Consults, and at least one at any remote location involved).
As Robert above mentioned, the MikroScan represents the personal slide scanner, the most versatile, but affordable aspect of the chain (4 MikroScan units are less than most single high throughput slide scanners).   Check us out, but most important, be sure to lay out a plan for your entire needs.


Victor Casas

Lisa M
Lisa M's picture
Thanks for the info! I should

Thanks for the info! I should've mentioned that we are really interested in a whole slide imager witha fluoresence component, which I noticed MikroScan has the iScan Concerto. Can you tell me some more about this? Also, is the MikroScan FDA approved? And speaking of software is the software that goes with the Conerto (the Virtuoso?) comaptable with other programs if you wanted to analyze your images with Image J, for example? And how advanced are the algorythms for, let's say, co-localization?


Jeremy T
Jeremy T's picture
Huron Technologies (www

Huron Technologies (www.confocal.com) manufactures the TISSUEscope, which is a fluorescent scanner.  It has the ability to image whole mount slides (up to 6" x 8").  This is ideal for large specimens or organs such has brains, breast, lungs and prostate.  Hope this helps.

FlagshipBio's picture
 Please contact us and we can

 Please contact us and we can give you a full assessment of the various whole slide scanning products on the market. We also offer digital pathology services, all of which are supervised by board-certified pathologists. Good digital pathology slide scanning requires careful manual QA after the scanning, this is very important, as there will always be slides you have to redo, no matter which digital pathology solution you choose.  In addition to hardware and software, you should also budget for two full-time FTEs, one person to scan and a second for image analysis, depending on how sophisticated you get. Like anything else, you get what you pay for in virtual microscopy

We can also do whole slide fluorescent scanning as a service. 

Lisa M
Lisa M's picture
As the histology core lab, we

As the histology core lab, we will be providing the scanning services to our researchers. Similiar to what you do for labs but just in our facility. I am interested in your assement of the scanners on the market and software. Our needs will probably be more research based (especially for fluoresence) but we may be supporting some clinical as well.

FlagshipBio's picture
 Great, please contact us via

 Great, please contact us via email and I can give you further information on digital pathology and particularly fluorescent slide scanning.  I can also give you some idea how researchers at academic medical centers are using whole slide scanning for tissue biomarkers and companion diagnostics.

You can see examples on our website of typical applications we commonly see at academic core labs:
Beta cell mass measurement
Glomeruli biomarkers
Tumor and stroma classification
Medical device image analysis
Measuring amyloid plaque
Xenograft image analysis

I can discuss with you what scanning equipment you will need for some of these common requests you are likely to get from your in-house academic customers.

Email: eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%70%61%74%68%73%65%72%76%69%63%65%73%40%66%6c%61%67%73%68%69%70%62%69%6f%2e%63%6f%6d%22%3e%70%61%74%68%73%65%72%76%69%63%65%73%40%66%6c%61%67%73%68%69%70%62%69%6f%2e%63%6f%6d%3c%2f%61%3e%27%29%3b'))

Digital Pathology Services