I like to know whether mRNA and Protein expression are always correlating. During time point studies, at 3 different time points, the first and last points of mrna expression are correlating with the protein in immunohistochemistry. but at the 2nd time point, the mrna is low but protein is the same
Is it the feed back effect due to retaining the proteins without degradation so that the mrna is downregulated. Are there any other reasons?
Thanks a lot