Biofilm-penetrant delivery systems for DNA-based antibiotics

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Amar Annamalai
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Biofilm-penetrant delivery systems for DNA-based antibiotics

Directly-Funded Studentship: Biofilm-penetrant delivery systems for DNA-based antibiotics active against lung pathogens

University of East Anglia - School of Pharmacy

Qualification type:
PhD

Location:
Norwich

Funding for:
UK Students, EU Students

Funding amount:
£14,057 plus a CASE top-up of £2500 per annum

Hours:
Full Time

Placed on:
3rd February 2015

Closes:
27th February 2015


Start Date:
October 2015.

Supervisor:
Dr Chris Morris, christopher.j.morris@uea.ac.uk

The Project:

Applications are invited for a 4-year PhD studentship to work on a multidisciplinary collaborative project between Dr Chris Morris and Procarta Biosystems Ltd (www.procartabio.com). 

Cystic fibrosis (CF) is a genetic disease that results in the production of highly viscous mucus in the respiratory tract. In the CF lung opportunistic pathogens such as Pseudomonas aeruginosa are inefficiently cleared from the airways and they form biofilm structures that are refractory to antibiotic treatment. 

The aim of this fully-funded 4-year PhD studentship is to develop a drug delivery system for a DNA-based antibiotic that penetrates though the mucus and biofilm matrices that are found within the lung of cystic fibrosis patients.

This PhD project brings together academic expertise in pulmonary macromolecule delivery with the novel antibiotic technology for treating antibiotic resistant bacteria developed by Procarta. The successful candidate will be jointly supervised by Dr Chris Morris at UEA and Prof. Michael McArthur at Procarta Biosystems. The student will receive extensive multidisciplinary training from both academic and industrial teams and will spend a minimum of 3 months in the laboratories of the industrial partner.

The PhD studentship will commence on 1 October 2015.  Please direct informal enquiries to Dr Chris Morris (christopher.j.morris@uea.ac.uk).

Entry Requirements:

Applicants should have a minimum 2:1 honours degree (or equivalent) in biological / biomedical sciences, microbiology, pharmacy or a related area. A relevant masters qualification and previous experience of proteomics and transcriptomics techniques would be an advantage.

Funding:

This 4 year PhD studentship is an MRC Industrial CASE Studentship in partnership with Procarta Biosciences Ltd. An annual stipend of £14,057 (plus a CASE top-up of £2500 per annum) is available to the successful candidate who meets the UK Research Council eligibility criteria.  These requirements are detailed in the RCUK eligibility guide which can be found at http://www.rcuk.ac.uk/RCUK-prod/assets/documents/documents/TermsConditionsTrainingGrants.pdf. In most cases UK and EU nationals who have been ordinarily resident in the UK for 3 years prior to the start of the course are eligible for a full-award. Other EU nationals may qualify for a fees only award

To discuss the application process or particular projects, please contact the: Admissions Office, email: pgr.enquiries.admiss@uea.ac.uk or telephone +44 (0)1603 591709.