siRNA delivery @ target RNA degradation with amphipathic peptide delivery

1 post / 0 new
Jon Moulton
Jon Moulton's picture
siRNA delivery @ target RNA degradation with amphipathic peptide delivery

Bartz R, Fan H, Zhang J, Innocent N, Cherrin C, Beck SC, Pei Y, Momose A, Jadhav V, Tellers DM, Meng F, Crocker LS, Sepp-Lorenzino L, Barnett SF. Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape. Biochem J. 2011;435:475–87. [Epub Jan 25 ahead of print]
Tested in HeLa, Huh-7 and Hek293T cultures.