SiRNA delivery for treatment of knok-in disease

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me.rajshekhar
me.rajshekhar's picture
SiRNA delivery for treatment of knok-in disease

 Respected members,

                                           i would like to know about how a SiRNA delivery can be used in the treatment of a genetic disorder
(deletion mutation) that can be produced by knock-in technology.

ThanQ in advance..

Abhishek Singh
Abhishek Singh's picture
 Si RNA are mostly inhibitory

 Si RNA are mostly inhibitory in action thus inhibit a protein's expression. So if increase in particular protein is cause of disease, one can use SiRNA for target protein to deal with disease. however method of its delivery will be very crucial. 

me.rajshekhar
me.rajshekhar's picture
 Thank you very much for your

 Thank you very much for your reply...One more thing i would like to know about is after sucessfull delivery of SiRNA  can we use plasmid expression technology for encoding a full length gene(normal gene). ?