Opening For Research Assistant - University of Edinburgh

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Amar Annamalai
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Opening For Research Assistant - University of Edinburgh

Research Assistant
Vacancy Ref: :     030318    
Closing Date :     04-Jun-2014
Contact Person :     eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%69%67%6d%6d%68%72%40%69%67%6d%6d%2e%65%64%2e%61%63%2e%75%6b%22%3e%69%67%6d%6d%68%72%40%69%67%6d%6d%2e%65%64%2e%61%63%2e%75%6b%3c%2f%61%3e%27%29%3b'))    
Contact Number :     0131 467 8400
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Maintaining Genetic and Chromosomal Stability in the Mammalian Germline

A research assistant post is available in the laboratory of Dr. Ian Adams at the MRC Human Genetics Unit in Edinburgh. The purpose of this post is to carry out molecular biology, biochemical and genetic research, to investigate molecular mechanisms which help maintain genetic and chromosomal stability in the mammalian germline.

Research in the Adams group is aimed at trying to find out how the correct number of chromosomes is transmitted from parents to their children. Mistakes in this process are very common in humans and cause miscarriage, infertility, and Down's Syndrome. Our approach to studying this problem is to identify and characterise the genes and proteins that play a role in maintaining genetic and chromosomal stability in the mammalian germline. We are particularly interested in a group of germline genome defence genes that help prevent mutations from arising in the germline. These germline genome defence genes act by suppressing the mutagenic activity of retrotransposons that are present in the mammalian genome. Interestingly, mutations in these germline genome defence systems cause severe problems for chromosome behaviour during cell division in the developing germline. Cell lines and transgenic mice carrying mutations in these genes will be used to study chromosome behaviour and gene function in embryonic stem cells, and the developing germ cells that will eventually become sperm or eggs. We are particularly interested in determining how chromosomes are accurately segregated to daughter cells in the mammalian germline, and the role of genome defence systems in this process.

The purpose of this post is to carry out molecular biology, biochemical and genetic research, to investigate molecular mechanisms which help maintain genetic and chromosomal stability in the mammalian germline.

Research methods and objectives
Our research is trying to find out how the body makes sure that parents pass the right number of chromosomes on to their children. Mistakes in this process are very common in humans and cause miscarriage, infertility, and Down's Syndrome.

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