pervasive transcription???

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chandan_10_08
chandan_10_08's picture
pervasive transcription???

Hello eveyone,

Can you help me with the term "pervasive transcription"....

Regards,
chanderbio

Sami Tuomivaara
Sami Tuomivaara's picture
chanderbio,

chanderbio,

Pervasive transcription means that most of the genome is being transcribed (pervasive = widespread).

One view in genomics business has been that most of the DNA in some organisms incuding humans is junk, or evolutionary baggage, and is not transcribed (let alone translated). Thus, the realization that most of the DNA is transcribed was surprising. So, people use the phrase "pervasive transcription" to emphasize the fact that transcription of DNA is widespread and not restricted to the small percentage of protein coding DNA.

Cheers,

chandan_10_08
chandan_10_08's picture
Thanks Suola. Is "pervasive

Thanks Suola. Is "pervasive transcription" a speculation in Genomics or there are any studies that prove the existence of pervasive transcription?

Sami Tuomivaara
Sami Tuomivaara's picture
chanderbio,

chanderbio,

It is a very real phenomenon, genome-scale transcriptomics studies have shown this...
Some review articles below.

Nature Reviews Genetics review:
http://www.nature.com/nrg/journal/v10/n12/abs/nrg2683.html

EMBO Reports review:
http://www.nature.com/embor/journal/v10/n9/abs/embor2009181.html

Briefings in Functional Genomics review:
http://bfgp.oxfordjournals.org/cgi/reprint/8/6/407

Cheers,

chandan_10_08
chandan_10_08's picture
Thanks Suola. I found the

Thanks Suola. I found the articles interesting and hope there is a much scope of research, in this field, in near future.

Regards,
chanderbio

chervitz
chervitz's picture
I have compiled a number of

I have compiled a number of links to the literature, popular press, and related websites pertaining to pervasive transcription here:

http://pervasivetranscription.com

Additional suggestions? Let me know (contact link at bottom of that page)