In the Nature methods of July 2008, J.S present the last applications
of the next-generation sequencing devices ( Applied Biosystems SOLid, 454 Roche, Illumina-solexa ).
Both sequencing platforms offer approximately similar read lengths, error rates and per-tag costs, but the distinction is specifically around the shotgun construction and the data analysis.
So I would like to discuss with the users of the Solexa method to know their feeling , about the device , the protocols, the limit of Solexa especially in the gene expression topic.
Thanks for your reply.