Can someone define an ENCODE region of human sequence? May I know what information does this database (ENCODE) contain?
You will find plenty of information on the ENCODE project here. Essentially, ENCODE is a project aimed at doing very detailed annotation/characterization of a representative subset of the human genomic sequence.
The project aims to analyze functional elements of DNA including in the 5'/promoter, introns and 3' region of gene/message.http://www.genome.gov/10005107
'The National Human Genome Research Institute (NHGRI) launched a public research consortium named ENCODE, the Encyclopedia Of DNA Elements, in September 2003, to carry out a project to identify all functional elements in the human genome sequence. The project started with two components - a pilot phase and a technology development phase.
The pilot phase tested and compared existing methods to rigorously analyze a defined portion of the human genome sequence (See: ENCODE Pilot Project). The conclusions from this pilot project were published in June 2007 in Nature and Genome Research [genome.org]. The findings highlighted the success of the project to identify and characterize functional elements in the human genome. The technology development phase also has been a success with the promotion of several new technologies to generate high throughput data on functional elements.'
The pilot project analyzed 1% of human genome.
NHGRI is also innvolved in other projects:modENCODE: DNA element analysis in model organisms ( fruit fly D. melanogaster, roundworm C. elegans)The Knockout Mouse Project a comprehensive and public resource comprised of mice containing a null mutation in every gene in the mouse genomeCancer Genome Atlas full-scale effort to systematically explore the entire spectrum of genomic changes involved in human cancer using genome analysis technologies
Ryan u r really informative.
Varsha, u gave a insight of addition works. thanks a lot..