What is the most needed software tool for Genomics today and in the future?
To this day, BLAST, or one of its many variants, is still central to most genomic analyses. In the future? I don't forsee BLAST being replaced by another algorithm any time soon.
MAQ is far more important in my day-to-day life than blast ever was. Of course, I am neck-deep in short reads these days! Blast will not die, but it has become less relevant due to the type of data we can obtain routinely now (i.e. short reads).