Immunology

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Amar Annamalai
Amar Annamalai's picture
Immunology

Is it possible to block complement activation at specific organ of the body?

Kristina Holmberg
Kristina Holmberg's picture
It is really hard to answer

It is really hard to answer your question, since it depends of what activation you would like to block. Any in particular?

Amar Annamalai
Amar Annamalai's picture
Yes. I want block C4

Yes. I want block C4 activation. Is it possible?

Kristina Holmberg
Kristina Holmberg's picture
You can try to create a

You can try to create a single-chain Fv antibody against C4. It has been done for C5 see reference below. The flip side is that severe side effects might occur in vivo.

Thomas TC, Rollins SA, Rother RP et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol1996; 33:13891401

verghi
verghi's picture
krihol wrote:

krihol wrote:

You can try to create a single-chain Fv antibody against C4. It has been done for C5 see reference below. The flip side is that severe side effects might occur in vivo.

Thomas TC, Rollins SA, Rother RP et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol1996; 33:13891401