I am looking for a commercially available chymase inhibitors but cannot find one online. Can anyone recommend or know where to get one?
I think you can buy alpha1-antitrypsin or chymostatin (C7268) from Sigma Aldrich.
They may be of help to you.
Chymostatin is non specific and cannot be used in vivo...
looking for chymase, not trypsin inhibitor. I guess they are not available commercially... ???
I sure can't find any.
I'm sorry, I was going by this paper (www.ncbi.nlm.nih.gov/pubmed/15169639)
Nippon Kayaku Co makes one called NK3201, as used in this paper.
I will have to figure out how to get it from Japan I guess.
Check this pdf. Authors proclaim it to be a specific chymase inhibitor but the full text article is not accessible. Check If you can access the same and figure out its availability.
I contacted these guys, apparently NK3201 is no longer in production.
More info on BCEAB, etc
Conversely, transgenic mice produced by microinjection
of chymase mRNA into the heart and other tissues with
selective overexpression by a promotor-fusion gene had excessive
AngII concentrations in the heart causing significantly
increased metalloproteinase (MMP-9) activities and decreased
collagen I synthesis (12). This observation illustrates the potential
role of chymase in heart remodeling. Finally, while
chymostatine has long been known to selectively inhibit chymase
activity, a whole new generation of orally active low–
molecular weight chymase inhibitors has recently become
of hamsters with myocardial infarction despite having no
effect on the infarction size (13); BCEAB, which improved
indices of LV function in cardiomyopathic hamsters (14),
possibly by interfering with the activation of transforming
suppress intimal hyperplasia after balloon injury (15) or to
prevent peritoneal adhesions after intraabdominal trauma (16).
The availability of such powerful tools will help to resolve
some of the remaining uncertainties about the
e.g., TEI-E-548, which was shown to increase survival; and finally NK-3201, which was shown toin vivo role of