Immune and nonimmune inflammatory response (paw edema induction)

1 post / 0 new
cindylee
cindylee's picture
Immune and nonimmune inflammatory response (paw edema induction)

Carrageenan can cause an acute and nonimmune inflammatory response (paw edema induction) whereas lipopolysaccharides induce immune inflammatory response.  

Carrageenan induced inflammatory response in rat involves 3 phases: an iniatial, second and third phases caused by the release of histamine and serotonin; bradykinin and prostaglandins, respectively. Both histamine and serotonin is chracterised by the increase of vascular permeability . Postaglandins mediate maximum vascular responses during the 3rd phase of inflammation.

Lipopolysaccharides binds to the CD14/TLR4/MD2 receptor which promotes the secretion of pro-inflammatory cytokines

Question: How to define nonimmune and immune inflammatory response in this case?