Carrageenan can cause an acute and nonimmune inflammatory response (paw edema induction) whereas lipopolysaccharides induce immune inflammatory response.
Carrageenan induced inflammatory response in rat involves 3 phases: an iniatial, second and third phases caused by the release of histamine and serotonin; bradykinin and prostaglandins, respectively. Both histamine and serotonin is chracterised by the increase of vascular permeability . Postaglandins mediate maximum vascular responses during the 3rd phase of inflammation.
Lipopolysaccharides binds to the CD14/TLR4/MD2 receptor which promotes the secretion of pro-inflammatory cytokines
Question: How to define nonimmune and immune inflammatory response in this case?