Could anybody help me to elucidate the role of TGFbeta?
I know that Treg and Ti use it to downregulate the responce to antigens. But this cytokine releases into the environment, where many different T cells exist. Does it always suggests that TGFbeta mediated suppression is nonspecific and acts as a simple downregulator of the total Teff cells activity.
Or some degree of specificity nethertheless exists?
TGFbeta and selectivity