I have some questions about TNFalpha that I am a little confused on. When you have TNFalpha binding on the cell....how does the cell decide which route to take. By route...I mean either inflammation or apoptosis. I have been reading in the literature about this...and what I have found is that once TNFalplha binds to its cognate receptor...it can recruit different adaptor proteins such as FADD, TRADD, etc. I know that FADD has a DED domain which can interact with the DED domain in procaspase 8 to activate it thus initiating apoptosis to happen. On the other hand, I have found that if the right adaptor proteins are recruiting you can also activate NFkappaB which can then translocate into the nucleus and transcribe anti-apoptotic factors such as Bcl-2, c-FLIP, etc.
I am pretty new to this topic so any help would be very much appreciated. Honestly, I am just overall confused how the cell knows which route to go after TNFalpha binding....or even FasL...Trail...etc...
Thread moved to inflammation sub-forum - Bishop