Complement regulatory molecules

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Amar Annamalai
Amar Annamalai's picture
Complement regulatory molecules

Can anyone tell me a chemical compound acting as complement regulator?

Fraser Moss
Fraser Moss's picture
A

A

Here are some papers about humanized or the humanization of cobra venom factor that depletes plasma of essential complement components

1: Fritzinger DC, Hew BE, Thorne M, Pangburn MK, Janssen BJ, Gros P, Vogel CW.
Functional characterization of human C3/cobra venom factor hybrid proteins for
therapeutic complement depletion.
Dev Comp Immunol. 2008 Aug 27. [Epub ahead of print]
PMID: 18760301 [PubMed - as supplied by publisher]

2: Vogel CW, Fritzinger DC.
Humanized cobra venom factor: experimental therapeutics for targeted complement
activation and complement depletion.
Curr Pharm Des. 2007;13(28):2916-26. Review.
PMID: 17979736 [PubMed - indexed for MEDLINE]

3: Brook E, Herbert AP, Jenkins HT, Soares DC, Barlow PN.
Opportunities for new therapies based on the natural regulators of complement
activation.
Ann N Y Acad Sci. 2005 Nov;1056:176-88. Review.
PMID: 16387686 [PubMed - indexed for MEDLINE]

4: Vogel CW, Fritzinger DC, Hew BE, Thorne M, Bammert H.
Recombinant cobra venom factor.
Mol Immunol. 2004 Jun;41(2-3):191-9. Review.
PMID: 15159065 [PubMed - indexed for MEDLINE]

5: Kock MA, Hew BE, Bammert H, Fritzinger DC, Vogel CW.
Structure and function of recombinant cobra venom factor.
J Biol Chem. 2004 Jul 16;279(29):30836-43. Epub 2004 May 5.
PMID: 15131128 [PubMed - indexed for MEDLINE]

6: Schlag G, Redl HR, Till GO, Davies J, Martin U, Dumont L.
Anti-L-selectin antibody treatment of hemorrhagic-traumatic shock in baboons.
Crit Care Med. 1999 Sep;27(9):1900-7.
PMID: 10507616 [PubMed - indexed for MEDLINE]

Amar Annamalai
Amar Annamalai's picture
Thank you very much

Thank you very much