Opening For Sr Sci, Trans Med Job : Seattle

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Amar Annamalai
Amar Annamalai's picture
Opening For Sr Sci, Trans Med Job : Seattle

 Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
The candidate will have responsibility for directing the scientific aspects of preclinical oncology drug development programs and translational medicine correlative studies in Immuno-Oncology. The successful candidate will work directly with corporate partners, cross-functional teams and project teams to support preclinical and clinical programs.
- Provide in-depth scientific expertise in the area of immunology, Immuno-Oncology, and/or tumor biology
- Manages scientific staff in design and execution of experiments to evaluate Immuno-Oncology drug candidates including drug candidate screening, lead optimization, mechanism of action, preclinical proof of concept studies, biomarker development and translational studies
- Develop and execute research plans to address complex scientific questions
- Assist in development of scientific strategy
- Manage internal projects in Immuno-Oncology drug development
- Serve on internal project teams and committees as scientific functional lead
- Work closely with corporate partners to support preclinical, translational and clinical development of cancer therapeutics.
- May manage external collaborations with academic and contract research laboratories
Specific Duties:
- Design and execute strategies for evaluating activity and mechanism of action of Immuno-Oncology drug candidates using key immune cell populations
- Develop in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials
- Critically analyze, interpret, report experimental results; provide insights into research strategies
- Supervise Associate Scientist(s) and/or Research Associate(s) as needed
- Lead Immuno-Oncology team meetings, provide scientific guidance and critical analysis of data
- Establish and maintain working relationship with contract laboratories and relevant academic collaborators
- Lead the Immuno-Oncology group in maintaining current awareness in area of expertise; enhance the scientific credibility of Celgene through contributions to the scientific literature (publications/presentations)
- Assume responsibility for writing non-clinical pharmacology study reports, invention disclosures, and contribute to the writing of investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
- Ph.D. degree in immunology, tumor biology or cellular biology with at least 2 years of successful post-doctoral experience, evidenced by a strong publication record, plus a minimum of 6 years of successful experience as a bench scientist in the biotechnology or pharmaceutical industry setting
- Extensive experience designing and developing primary immune cell assays using key immune cell populations: CD4+ and CD8+ T cells, Tregs, NK cells, dendritic cells, MDSCs, and in-depth understanding immunologic pathways
- Proficiency with scientific research strategies and methods related to biomarker research and development
- Relevant skills include proficiency in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, etc.), cell biology (transient and stable engineering of cell lines, also using viral transduction, immunocytochemistry, microscopy), and molecular biology (molecular cloning, transient and stable gene silencing, recombinant protein engineering) techniques
- Extensive working knowledge of biomedical research methodologies and current technologies and experience in the drug development process from discovery through IND filing in an industry setting
- Excellent communication and interpersonal skills demonstrated in a team environment
- Excellent team building and teamwork skills and ability to interact with and manage research scientists, project teams, outside collaborators and commercial vendors
- Previous experience with supervision and mentoring of laboratory scientific staff
- Experience with evaluation and due diligence of research programs and technologies
- Detail-oriented with the ability to identify and implement creative solutions
- Ability to prioritize and manage time efficiently
- Experience with clinical research and an understanding of the research process, validation, and regulations that apply to clinical investigations and laboratory studies that support regulatory submissions is also highly desirable
Skills/Knowledge Required:
The incumbent must have planning skills for scheduling experimental studies to meet project team deadlines. The position requires problem solving ability and skills in resolving technical questions in a multi-disciplinary environment. The incumbent must keep abreast of current techniques within the field and the various scientific areas affecting normal and tumor cell growth.
Supervises internal research staff as required.
The position is responsible for planning and executing research plans in the defined area of investigation. This position has responsibility for the quality, quantity, timeliness, and scientific acceptability of drug discovery activities that result in reports that are required for internal decision-making.
CONTACTS: Principal recurring contacts, including their frequency and purpose.
Frequent contact with various levels of R&D.
Moderate contact with CROs and laboratories, universities and appropriate professional groups as necessary.
Domestic and international travel to scientific conferences may be required.
Req ID: 14002856
Primary Location: United States-Washington-Seattle
Job: Research and Development
Organization: Celgene Corporation
Schedule: Regular
Shift: Standard
Employee Status: Individual Contributor
Job Type: Full-time
Job Level: Day Job
Travel: Yes, 10 % of the Time
Job Posting: 2014-10-21 00:00:00.0
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