Director, Signal Transduction

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Director, Signal Transduction

Job Description
Org Marketing Statement
Pfizer Inc: Working together for a healthier world

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.

Role Description
Reduce to practice the strategic vision of bringing first-in-class oncology therapies to the clinic, and of significantly improving probability of success across the portfoli o. Design and implement a strategy to comprehensively validate cancer drug targets. Direct biology efforts for drug discovery programs in signal transduction.

Primary Duties:

- Lead a team of scientists dedicated to Cancer Biology, Target Validation and Drug Discovery using in vitro, in vivo, and omics methodologies, in collaboration with partner lines
- Participate in nomination of new potential targets from literature; collaborates with IBB to fully validate targets originating in that group
- Direct genetic and pharmacologic strategies to validate signal transduction targets
- Identify, develop, and manage external collaborations with world class experts to advance our competitive advantage in improved target validation and drug discovery
- Partner with collaborators and computational biologists, to integrate data and further enhance understanding of target biology
- Ensure scientific rigor across team and focus resources towards TCB and company goals
- Contribute to building a culture that embraces continuous learning and improvement, increasing technical skill base and disease biology expertise; take a proactive role in personal growth and scientific development
- Mentor staff scientists and postdoctoral fellows

Training & Education:

- PhD or MD/PhD plus post-doctoral training in Cell Biology, Molecular Biology, Biochemistry (or a comparable biological science) with a cancer-related focus
- Deep and broad knowledge of targets and pathways of importance to cancer biology
- Established expert in signal transduction
- Expert in advanced in vitro and in vivo models; good understanding of relevant methodologies ( e.g. phosphoproteomics)
- Effective manager of scientific teams
- Thorough knowledge of the entire drug discovery process, with good understanding of drug development

Prior Experience:
- At least 12 years experience working primarily on cancer biology and signal transduction
- At least 8 years experience in industry or academic lab focused on target validation and drug discovery
- Demonstrated ability to identify, develop, and manage successful external collaborations
- Able to work in a team environment; excellent communication skills
- Demonstrated success in designing and implementing strategy
- Track record of innovation – designing and delivering novel solutions to challenging problems

Equal Employment Opportunity
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S. For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site. Pfizer may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague's long-term prospects for securing lawful permanent residence, among other reasons. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer's support of a colleague's temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the colleague and Pfizer.
La Jolla, CA
United States

Deadline: Contact employer

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