Scientist I/II - Neurodegenerative diseases

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Amar Annamalai
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Scientist I/II - Neurodegenerative diseases

A new team of lab-based scientists is being established within the neuroscience innovative medicines unit (IMED), based in Cambridge, UK, with responsibility for delivering a range of assays to support the current project portfolio in analgesia, neurodegeneration and an emerging psychiatry portfolio, as well as activities to identify and validate new targets for these diseases. 
The team will have the opportunity to work extensively with the external scientific community, which may include formal management of external collaborations. The team will work closely with a similar team based in Boston, USA, and will have the opportunity to work on and develop skills in drug discovery for both large molecules (biologics) and small chemical entities.
This role is suited to a lab-based expert in Neurodegenerative diseases, with experience of in cellular assays relevant to eg Alzheimer's disease, Parkinson's disease; ideally with some molecular biology experience. The successful candidate will support ongoing Neurodegeneration drug discovery projects and provide input on target validation for new approaches coming forward.
Your previous experience will include:

  • Have expertise in neurodegeneration, in particular hands-on expertise in the generation and use of oligomeric protein preparations eg amyloid, tau, synuclein, TDP43, huntingtin, in the context of cell based assays 
  • Provide strong expertise in primary cell culture, including neuronal and glial cultures. 
  • Be responsible for design and execution of functional in vitro assays, predominantly cellular, for a range of target classes. 
  • Be expected to provide pharmacological interpretation of assay results and understand principles of competition, quantitative pharmacological analysis, affinities, IC/EC50 etc 
  • Have expertise in the use of molecular biology techniques eg cloning, PCR, RNAi  
  • Work within a line and/or matrix team, which may also encompass working within a multifunctional project team as the in vitro pharmacology representative. 
  • Lead the biology for early discovery projects including understanding mechanism of action and signalling pathways. 

The role also requires:

  •  Experimental work to be performed in accordance with established SOPs and codes of conduct

Deadline: 15 November 2013

For more details