A Postdoctoral Fellow/Research Assistant position is available at the Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada. Dalhousie University is a great academic institution in Canada. It has consistently been ranked one of top universities in Canada and in the world by Times Higher Education World University Rankings, QS World University Rankings, and Academic Ranking of World Universities. Meanwhile, Halifax, a beautiful seaside city where Dalhousie is located, is ranked # 2 in the list of ‘best places to live’ in Canada.
This position is created for a person who is interested in investigating the functions of lysosomes with a focus on lysosomal ion channels. Lysosomes are traditionally viewed as ‘cell stomachs’ (degradation through endocytosis, autophagy, phagocytosis). Recent research, however, indicates that lysosomes also play important roles in a variety of cellular functions including endo-exocytic membrane trafficking, signal transduction, gliotransmitter release, neurite outgrowth, insulin secretion, and plasma membrane repair. Lysosomal ion channels/transporters play essential roles in the aforementioned functions of lysosomes. To understand lysosomal channels/transporters in their native environments, my group recently developed a unique lysosomal patch-clamp technique (Nature, 2008; Nature Commun, 2010; Nature Commun, 2012; Cell, 2012), which has opened a new avenue for the research of lysosomal ion channel and related diseases. Primary interests of my lab are lysosomal ion channels and their physiological/pathological implications. Investigation of these lysosomal channels will facilitate our understanding of the pathogenic mechanisms of many human diseases including neurodegenerative diseases, lysosomal storage diseases, stroke/ischemia, and aging. Competitive applicants will be motivated individuals with expertise in molecular/biochemistry/cellular biology and/or patch-clamp electrophysiology. Background in ion channels, neurobiology, and experience with calcium imaging, confocal microscopy, and mouse genetics, and desire to learn new techniques are additions. To apply, please send cover letter detailing your experience, a copy of your CV and contact information for three references to Dr. Xianping Dong (firstname.lastname@example.org).
Deadline: Contact employer