Postdoctoral Research Assistant in Structural Biology

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Postdoctoral Research Assistant in Structural Biology

University of Edinburgh

We are seeking an ambitious, enthusiastic, highly motivated postdoctoral researcher to investigate the structural biology of the membrane-attack complex (MAC) whose role is to destroy invading bacteria. The MAC is a potentially cytolytic trans-membrane pore that self-assembles in a remarkable and little-understood process from soluble protein components. This BBSRC-funded project will address the molecular mechanisms that minimise MAC-mediated "collateral" damage to healthy host tissue.
You will produce and purify recombinant proteins, and then use biophysical and structural techniques to characterise them and their complexes. The principal techniques to be employed might include NMR spectroscopy, X-ray crystallography, small-angle X-ray scattering and mass spectrometry (combined with chemical cross-linking). You will also supervise more junior lab members and become involved in a variety of closely related projects.
You will have completed a PhD project that involved either structural biology or protein overproduction. You will have a good knowledge of protein structure and biophysical methods. You will have demonstrated a high level of success in your work as evidenced by your publication record.
Fixed Term: 3 years
Salary Scale:  £29,972 - 35,788
Please Quote Ref: 3014168
Closing Date: 31 March 2011
For further particulars and an application pack visit our website ( or telephone the recruitment line on 0131 650 2511.

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