DISCOVERY OF TRANSDERMAL PENETRATION ENHANCERS BY HIGH-THROUGHPUT SCREENING. Karande, P., Jain, A. and Mitragotri, S. Department of Chemical Engineering, University of California, Santa Barbara, CA. Nature Biotechnology, 22, (2), 192-197, (2004)....
The discovery of these mixtures was enabled by an experimental tool, in vitro skin impedance guided high-throughput (INSIGHT) screening, which is >100-fold more efficient than current tools ie Franz cells.
My attempted communications with the authors has been fruitless. Has anyone had experience with this INSIGHT method? My work has confirmed the efficacy of the mixtures discovered using this screening tool, but I'm clueless as to the apparatus used in this method.