Tumor Killing Nanoparticles

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Tony Rook
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Tumor Killing Nanoparticles

Here are a few links to some promising technology that used iron oxide nanoparticles that were coated with peptides specific to clots within tumor blood vessel walls. These nanoparticles subsequently would induce more clotting which attracted even more nanooparticles which could eventually choke off blood source for the tumor.

Thinking Big with The Very Small: Focus of New Cancer Nanotechnology Center at UCSD
University of California, San Diego Medical Center Moores Cancer Center

The focus of the UCSD team will be to develop mother ships, smart nanoplatforms capable of homing in on tumors and delivering payloads of smaller particles to perform various tasks in the tumors. About the size of a red blood cell, these micron-sized nanoporous mother ships would move through the body, target specific tumor cells or the blood vessels that feed them. After arriving at their destinations, mother ships would release their payload nanoparticles, which could be designed to help image tumors, enter cells and perform measurements, and deliver therapies. Chemists at UCSD together with materials scientists at the University of California, Santa Barbara nanofabrication facility will synthesize nanoparticles that will be coated with biolinkers, molecules developed at the Burnham Institute to make the particles attach to specific types of tumor cells.

Homing nanoparticles pack multiple assault on tumors

A collaborative team led by Erkki Ruoslahti, M.D., Ph.D., of the Burnham Institute for Medical Research at UC Santa Barbara (Burnham) has developed nanoparticles that seek out tumors and bind to their blood vessels, and then attract more nanoparticles to the tumor target. Using this system the team demonstrated that the homing nanoparticle could be used to deliver a "payload" of an imaging compound, and in the process act as a clotting agent, obstructing as much as 20% of the tumor blood vessels.

Tumor-Killing Nanoparticles A new class of imaging particles seeks out cancers' blood vessels. Technology Review

heehawmcduff
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Iron oxide can be a fairly

Iron oxide can be a fairly reactive particle in cell culture systems - I wonder what the toxicity tests will show in this situation.  For example, is there increased necrosis at the site of delivery?