PhD Studentship - Developmental Neurobiology

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Amar Annamalai
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PhD Studentship - Developmental Neurobiology

PhD Studentship - Developmental Neurobiology

The Francis Crick Institute

Location:
London

Funding for:
EU Students, International Students, Self-funded Students, UK Students

Funding amount:
Not specified

Hours:
Full Time

Placed on:
12th February 2015

Closes:
6th March 2015

Reference:
213

The Francis Crick Institute is a partnership between Cancer Research UK, the Medical Research Council, the Wellcome Trust, UCL (University College London), Imperial College London and King's College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.

The institute will be a world-leading centre of biomedical research and innovation. It will promote connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute will have the scale, vision and expertise to tackle the most challenging scientific questions underpinning health and disease. It will be world-class with a strong national role—training scientists and developing ideas for public good. Due to open in 2015, the Crick will be located in a new, purpose built research centre in Brill Place, St. Pancras and will house some 1,500 staff.

The position of PhD studentship has been created to address the roles of LATS1/2 kinases in mammalian neuronal development and synaptogenesis. The student will perform experiments using transgenic mice to determine the requirement of LATS1/2 kinases in hippocampal synaptogenesis. For this she/he will use electrophysiology and imaging techniques. She/he will then utilize biochemistry, chemical genetics and mass spectrometry techniques to identify downstream effectors of LATS1/2.

Organisation

The PhD student will be working mainly in the Ultanir lab to conduct her PhD project. He/she will also be a part of our collaboration with Dr. Bram Snijders who heads the Proteomics and Mass Spectrometry Laboratory at Crick, where she/ he will receive mass spectrometry training and perform these experiments.

For more details on the project: http://www.crick.ac.uk/media/178635/213._crick_job_description_and_person_specification_-_phd_studentship_-_developmental_neurobiology.pdf

Objectives

  • Specific objectives will include, but not be limited to:
  • Characterization of Lats1/2 conditional knockout mice by electrophysiology and neuronal dendrite and spine morphology
  • Identification of LATS1/2 downstream effectors using chemical genetic methods and mass spectrometry
  • Molecular characterization of LATS1/2 and its substrates in cultured neurons.


Person Specification

  • The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegiate, in addition to the following:


Essential

  • Applicants must hold or expect to gain a first/upper second-class honours degree or equivalent in a relevant subject
  • Neuroscience knowledge
  • Experience in protein biochemistry
  • Interest in protein signalling mechanisms
  • Motivation in learning techniques including mouse genetics and mass spectrometry


Desirable

  • Knowledge of molecular biology
  • Knowledge of mass spectrometry

If you would like to apply for this role please follow the application instructions which can be found at http://www.nimr.mrc.ac.uk/phd/.

For further details about the PhD programme see http://www.crick.ac.uk/about-us/phd-programme/

The closing date for applications is Friday 06 March at 12pm.

Should you have any queries relating to this role, please contact
studentships@nimr.mrc.ac.uk.