How do people decide which intracellular solution to use? Why would you choose K+ based versu Na based? What are the best intracellular solutions for recording minis vs whole cell LTP etc.? Is there an intracellular solution that's best for switching between recording a cell's firing characteristics (current clamp mode) then going whole cell and recording minis? I'm trying to patch interneurons (blindpatch) so I need to be able to characterize them eletrophysiologically before recording minis-is this possible? The literature doesn't provide specifics and usually people use biocytin to backfill and then posthoc identify cells. I need the quickest way possible without posthoc identification using confocal. Are there other gudes for using multiclamp to do the current clamp and voltage clamp exp's besides the Axon guide? Can someone recommend literature or books that more specifically address intracellular solution composition logistics and switching between current clamp and voltage clamp for interneuron recordings? I don't have any training and have been pretty much teaching myself on the fly how to use this software and do these recordings. I've tried visualized patch but have found that I my cells are healthier with blind patch. Any tips for improving success rate for visualized patching (less positive pressure, less suction during attempted patching relavite to blindpatch etc?).