Modulators for Membrane Potential

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vilsy
vilsy's picture
Modulators for Membrane Potential

Hi Guys,
I usually use voltage clamp to alter the membrane potential. I was wondering if someone can recommend me some chemical modulators to change the membrane potential and increase the excitability of cells.
Thanks,
V

Morgado
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vilsy wrote:

vilsy wrote:

Hi Guys,
I usually use voltage clamp to alter the membrane potential. I was wondering if someone can recommend me some chemical modulators to change the membrane potential and increase the excitability of cells.
Thanks,
V

You can increase MP and the excitability of your cells using KCl 40 - 140 mM in the extracellular bath solution. But you should be careful not to alter the osmolarity of the bath solution when increasing KCl concentration.

Fraser Moss
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As said above depolarization

As said above depolarization an be induced by elevation of external K+. For the opposite effect - hyperpolarization add external cromakalim

vilsy
vilsy's picture
Thanks guys.

Thanks guys.