Molecule of the Year 2007 is the PKD2L1

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Isidro A. T. Savillo
Isidro A. T. Savillo's picture
Molecule of the Year 2007 is the PKD2L1

The Molecule of the Year 2007 is the PKD2L1.

Through the discretion of the President of ISMCBBPR (International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches), the Molecule of the Year 2007 is the PKD2L1. PKD2L1 is the fourth taste receptor identified which detects sour taste and was found expressed by particular cells in taste buds. Moreover the techniques (e.g. bioinformatics, etc.) and molecular protocols which were used to scout and subsequently locate these ionic channels were profound and exceedingly exciting. In addition, Charles Zuker and his team were also known to identify other mammalian taste receptors (e.g. for sweet, bitter and umami). "The honor bestowed upon PKD2L1 embodies all the other taste receptors they discovered and will uncover in the near future," says Prof. Isidro T. Savillo, President of ISMCBBPR. Congratulations to Dr. Charles Zuker and his Team!!

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Guy Sovak
Guy Sovak's picture
Thank you Prof. Savillo,

Thank you Prof. Savillo,
It is very interesting to read the information about the PKD2L1 receptor.
Hope to get more interesting information from you.
I am adding few other articles about the receptor:

1) Ishimaru Y, Inada H, Kubota M, Zhuang H, Tominaga M, Matsunami H, Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74. Epub 2006 Aug 4.

2) Sutton KA, Jungnickel MK, Ward CJ, Harris PC, Florman HM.
Functional characterization of PKDREJ, a male germ cell-restricted polycystin. J Cell Physiol. 2006 Nov;209(2):493-500.

3)LopezJimenez ND, Cavenagh MM, Sainz E, Cruz-Ithier MA, Battey JF, Sullivan SL. Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. J Neurochem. 2006 Jul;98(1):68-77.