biochemical changes in pathological conditions in human body????????

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strider_052
strider_052's picture
biochemical changes in pathological conditions in human body????????

hi.... kindly if any one has any information about above mentioned topic so plz let me know i have to prepare an assignment on the said topic.

Omai
Omai's picture
Hey strider52,

Hey strider52,
That is a very open ended question. I immediately thought of metabolic diseases. These diseases are usually a result of a faulty enzyme that lead to a build up (or lack) of a necessary biochemical product in the body. The disease pathology varies widely depending on the metabolic disorder. Wiki is a good place to start:
en.wikipedia.org/wiki/Inborn_error_of_metabolism
And some other starting points:
www.nlm.nih.gov/medlineplus/metabolicdisorders.html
emedicine.medscape.com/article/804757-overview
I would just choose one type of disease (like lysosomal storage disorders), google search, and start writing.
Good luck.
Omai

varsha
varsha's picture
Hi.

Hi.
Like Omai said, you have to pick a pathological conditions e.g. a metabolic disease and then go thru the extensive literature you will find.  You have the option of picking the pathological condition you like.
You could make it more interesting by discussing the  the metabolic profile for the condition if available.
Metabonomics is the study of how the metabolic profile of a complex biological system changes in response to stresses like disease, toxic exposure, or dietary change.
The goals of Metabolomics are to catalog and quantify the myriad small molecules found in biological fluids under different conditions.- by usng NMR(mostly) on biological fluids
It is being done not only for genetic metabolic disorders for also for infection e.g metabolomics on cerebrospinal fluid from patient with Cryptococcus neoformans infection
You may find the following resources to be useful:
Human Metabolite Database
Human Metabolite Library
MMCD Madison Metabolomics Consortium Database
MDL Sweden
other Metabolomics links

strider_052
strider_052's picture
THANX ALOT OMAI AND VARSHA

THANX ALOT OMAI AND VARSHA FOR GIVING ME SUCH HELPFUL INFORMATION.