Dendritic Cell Antigen Presentation

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Amtekoth
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Dendritic Cell Antigen Presentation

I was wondering how rapidly a mature DC, when pulsed with an antigen in vitro, presents it on the surface (for detection purposes)?

Is there a big time difference between a peptide and a whole protein?

Thanks for any help here.

Ed

Tracy
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peptide should be quicker in

peptide should be quicker in presentation than the whole protein, cause protein needs to be processed in order to be presented on the surface.

Amtekoth
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Thanks, I understand that the

Thanks, I understand that the peptide doesn't need the same processing that a whole protein does, but what is the timescale here? A few hours? A few minutes? A day?

Ed

coltifer
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I believe its a few hours,

I believe its a few hours, but I don't have a reference for that. I asked the same question to a visiting professor last week who's research area was antigen presentation.