SCID vs Rag

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coltifer
coltifer's picture
SCID vs Rag

Can someone tell me why Rags are better than SCIDS? I've heard that SCIDS are leaky. Pointing me where to find this information would be great too.

marcus muench
marcus muench's picture
Try this reference:

Try this reference:

Meyerrose TE et al. Immune-deficient mouse models for analysis of human stem cells. Biotechniques 35:6, 1262-72 (2003)

"The current review discusses the merits and drawbacks of each immune-deficient mouse xenograft system as it stands to date and reviews how each immune-deficient mouse model has been used to further our knowledge of human hematopoietic stem cell biology."