Neuroscience Computational Biologist

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Amar Annamalai
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Neuroscience Computational Biologist

About Novartis Institute of Biomedical Research  

At Novartis Institutes for BioMedical Research (“NIBR”), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded. It is ultimately the talent of the individual that determines our success, while our state-of-the-art technologies and resources enable these ideas to be realized. NIBR has sites in Cambridge, Massachusetts; Emeryville, CA; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Cambridge, MA, location is the global research headquarters and has focuses in areas including Pathway Biology, Oncology, Ophthalmology, Metabolism, Muscle, Epigenetics, and Regenerative Medicine.  It has a variety of positions in Biology, Chemistry, Biologics, Protein Sciences, and other technologies and additionally in functions such as Patents, Computational Resources, Alliance Management, Operations and other areas that support our scientific resources. Developmental & Molecular Pathways
The Developmental and Molecular Pathways (DMP) Group strives to better understand the molecular anatomy of disease by defining key developmental genetic pathways and druggable nodes pathways such as Wnt, TGF-beta, Hedgehog, Notch, mTOR, and PI3K pathways.  The goal of DMP is to identify and validate novel targets (druggable nodes in the pathways) with a focus on: tumor biology, stem cell biology (regenerative medicine), neuro/muscular degeneration, human genetics and epigenetics, and immunology. DMP's core capabilities in pathway analysis for target identification/validation include: genomics, proteomics, model organisms, screening, and computational biology.

Job Description / Key Responsibilities
As a member of the Department of Developmental and Molecular Pathways, you will be working in a dynamic, agile ‘dry-lab’ research environment committed to the discovery of novel medicines for neurological diseases.  You will be providing critical support to colleagues by working closely with other investigators to develop mechanistic hypotheses underlying cognitive and degenerative disorders.  You will draw on your background investigating the nervous system in either model systems or clinical studies as you work collaboratively with programmers, statisticians, and experimentalists to provide high quality, timely analyses of large scale experimental data.  Your background must demonstrate a proven ability to work collaboratively to provide high quality research in a timely manner.
Minimum Requirements
The successful candidate will have a Ph.D. degree in computational biology, bioinformatics, neuroscience, cell and developmental biology, or a related field.
Highly sought attributes include:

  • Excellent interpersonal and communication skills
  • Experience in wet lab investigation of pathways and processes
  • Experience with Spotfire and R/Bioconductor
  • Experience with ‘omic data analysis – particularly NGS, microarrays and proteomic technologies
  • Experience with morphometric data analysis
  • Experience with electrophysiology data analysis
  • A demonstrated understanding of statistics and quantitative data analysis
  • Experience with Perl (or other scripting languages), SQL, and relational databases an advantage
  • Some  industry experience preferred

Deadline: Tuesday, 20 August 2013

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