Job Ref: 81957
Fixed-term for 3 years (Part-time)
We are seeking an outstanding Senior Bioinformatician to contribute to the building of a medically important set of mouse genome sequences and contribute to the comparative analysis as part of the Mouse Genomes Project (http://www.sanger.ac.uk/resources/mouse/genomes/).
The Mouse Genomes Project is an ongoing effort to sequence the genomes of the common laboratory mouse strains, cataloging all forms of molecular variation, and to produce genome sequences of each strain. Phase 1 (2008-2011) of the project involved deep sequencing of the strains and creating comprehensive catalogs of molecular variation ranging from single base changes up to large structural differences of multiple kilobases (1, 2). We are now in phase 2 (2012 onwards) of the project with the focus being the production of accurate genome sequences, strain specific gene annotation, and comparative analysis of the strains.
The Wellcome Trust Sanger Institute is a world leader in delivering large scale genome sequencing projects using the latest sequencing technologies. The Sequence Variation Infrastructure team work as part of the Computational Genomics programme with responsibility for development of highly used next-generation sequencing software packages (e.g. Samtools), development of systems to query across large volumes of sequencing data, contribute to the 1000 genomes project and the Global Alliance (http://genomicsandhealth.org/) data working group, and lead the Mouse Genomes Project. One of the key challenges of this role will be to work on large sequencing datasets in parallel, whilst maintaining high data and analysis quality standards.
This role would suit somebody with some previous bioinformatics experience or a newly qualified graduate student who wishes to gain direct knowledge of next-generation sequencing technologies and analysis. The successful candidate will work closely with established team of analysts and developers so previous experience with next-generation sequencing data is not strictly necessary.
(1) Keane et al. (2011) Mouse genomic variation and its effect on phenotypes and gene regulation, Nature 477, 289-294
(2) Yalcin et al. (2011) Sequence-based characterization of structural variation in the mouse genome, Nature, 477, 326-329
Demonstrable record in bioinformatics
Advanced degree (e.g. PhD) or equivalent research experience Demonstrable record of computational data analysis Excellent communication skills (written and verbal) Proficiency in one or more scripting languages
Familiar with working on the unix command line NGS data analysis Knowledge of genome assembly Experience in comparative genomics Knowledge of mouse genetics or genomics
Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.
To apply, please complete our application form and include a CV and covering letter
Opening For Senior Bioinformatician - Hinxton
Job Ref: 81957