Synaptopathies: dysfunction of synaptic function

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Jitendra Sinha
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Synaptopathies: dysfunction of synaptic function

Synaptopathies: dysfunction of synaptic function





Meeting background
Molecular, biochemical and genetic analysis of synaptic function have converged with physiological and anatomical approaches to open up a large increase in our understanding of signalling that controls brain function. As in all branches of bio-science the ability to more precisely define normal function has the benefit of allowing a better detailing of the mechanisms that underpin disease. The expanded understanding of synaptic mechanisms has led to investigators to more directly address if disruption of synaptic pathways mediate or act as the primary site of disease processes. This has been articulated in the term Synaptopathy as a way of describing disease states that are primarily driven from dysfunction in the synaptic sub-compartment. This is manifest in the most current ideas to explain key features of the major neurodegenerative (e.g. Alzheimers) and psychiatric diseases (e.g. autism).

This meeting will address the issue of synaptopathy. It will be driven by discussion of investigations that continue to drive a basic understanding of the biochemical and cellular process of normal synaptic function. The key note speakers will discuss their current work while building a picture of the complexity and diversity of synaptic form and function. Further we will include speakers whose work on these basic mechanisms are now informing a further understanding of synaptic dysfunction with a view to addressing how core synaptic biochemistry can impact on disease. Speakers will discuss this by focussing on animal models or clinical material in which there is evidence for synaptic dysfunction. As a final agenda to the meeting we plan to drive discussion through key note speakers of the potential for synaptopathy in major disease processes to allow for the development of novel drugs or therapeutic treatments. Overall the meeting will endeavour to capture the communities increasing relish for translating our understanding synaptic form and function into potential for major brain disorders.







Wednesday, September 2, 2009 12:00 PM - Friday, September 4, 2009 2:30 PM

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